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J Neurochem 105:11441152 Franco R, Cidlowski JA (2009) Apoptosis and glutathione: beyond an antioxidant

CHAC1 supports Fe-S protein function under cystine deprivation The maintenance of Fe-S cluster synthesis under cystine starvation argues for the existence of an alternative source of mitochondrial cysteine

Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors

Moreover, 4E-BP expression in Drosophila muscles is able to improve systemic proteostasis and promote lifespan extension (Demontis and Perrimon, 2010), in line with a later mouse study showing that 4E-BP1 activity in muscles influences organismal metabolism during aging (Tsai et al., 2015)

To this extent, we detected a reduction in CD95 + GL-7 + GC B cells in Gclc fl/fl Mb1-Cre + mice compared to controls (Fig